Polyhydroxylated GdDTPA-derivatives as high relaxivity magnetic resonance imaging contrast agents

Novel GdDTPA-like complexes bearing differently branched, highly hydrophilic, gluconyl moieties were synthesized to obtain high relaxivity agents (∼20 mM⁻¹ s⁻¹ at 25 °C) over a wide range of imaging fields (0.5–3 T).