免疫原性
单克隆抗体
人性化鼠标
计算生物学
人源化抗体
抗体
功能(生物学)
免疫系统
计算机科学
免疫学
生物
细胞生物学
标识
DOI:10.1002/9783527682423.ch5
摘要
Humanization of monoclonal antibodies (mAbs) from animal sources comprises strategies for reducing their immunogenicity and for improving their activation of the human immune system. There are now many humanized mAbs in late phase clinical trials and several have been given approval to be used as biopharmaceuticals. Although the mechanics of producing the engineered mAb using the techniques of molecular biology are relatively straightforward, the design of the humanized antibody sequence is critical for reproducing the affinity, specificity, and function of the original molecule while minimizing human anti-mouse antibody (HAMA) responses elicited in patients. There are many strategies leading to the design of the humanized variable regions (Fvs) and thus various choices are open to the antibody designer. These strategies and choices are the subject matter of this chapter.
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