体内
离体
Zeta电位
纳米颗粒
表面电荷
生物物理学
扩散
材料科学
体外
药物输送
纳米技术
黏膜黏附
化学
毒品携带者
生物化学
物理化学
生物
物理
生物技术
热力学
作者
Aharon Azagury,Cameron Baptista,Kosta Milovanovic,Hyeseon Shin,Peter Morello,James Perez‐Rogers,Victoria Goldenshtein,Travis Nguyen,Arianna Markel,Soham Rege,Stephanie Hojsak,Alexander Perl,Carder Jones,Megan Fife,Stacia Furtado,Edith Mathiowitz
出处
期刊:Small
[Wiley]
日期:2022-05-23
卷期号:18 (26): 2107559-2107559
被引量:2
标识
DOI:10.1002/smll.202107559
摘要
Decades of research into the topic of oral nanoparticle (NP) delivery has still not provided a clear consensus regarding which properties produce an effective oral drug delivery system. The surface properties—charge and bioadhesiveness—as well as in vitro and in vivo correlation seem to generate the greatest number of disagreements within the field. Herein, a mechanism underlying the in vivo behavior of NPs is proposed, which bridges the gaps between these disagreements. The mechanism relies on the idea of biocoating—the coating of NPs with mucus—which alters their surface properties, and ultimately their systemic uptake. Utilizing this mechanism, several coated NPs are tested in vitro, ex vivo, and in vivo, and biocoating is found to affect NPs size, zeta-potential, mucosal diffusion coefficient, the extent of aggregation, and in vivo/in vitro/ex vivo correlation. Based on these results, low molecular weight polylactic acid exhibits a 21-fold increase in mucosal diffusion coefficient after precoating as compared to uncoated particles, as well as 20% less aggregation, and about 30% uptake to the blood in vivo. These discoveries suggest that biocoating reduces negative NP charge which results in an enhanced mucosal diffusion rate, increased gastrointestinal retention time, and high systemic uptake.
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