铱
化学
苯胺
催化作用
烷基化
腙
氢
组合化学
高分子化学
吡啶
光化学
药物化学
有机化学
作者
Yan Wang,Fang-Lei Zhang,Zhen‐Jiang Liu,Zhonghua Yao
出处
期刊:Inorganic Chemistry
[American Chemical Society]
日期:2022-06-29
卷期号:61 (27): 10310-10320
被引量:10
标识
DOI:10.1021/acs.inorgchem.2c00703
摘要
Here, we synthesize a series of hydrazone-based N,O-chelate half-sandwich iridium complexes through a facile route. All air-stable iridium complexes show high catalytic activity in N-alkylation of a broad scope of aniline derivatives and alcohols with liberating water as the sole byproduct. This reaction provides a smooth route to synthesize diverse monoalkylated amines in good to excellent yields at moderate temperature with a low catalyst loading. Moreover, the challenging N-alkylation process using nitroarene substrates as coupling partners is also carried out in this catalytic system. The mechanistic study shows that the present iridium catalysis process proceeds through a hydrogen borrowing mechanism. All iridium(III) complexes 1-4 are characterized by infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and elemental analysis.
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