Diagnostic Performance of a Noninvasive Breath Test for Colorectal Cancer: COBRA1 Study

Colorectal cancer (CRC) is the third most common cancer globally.1 When diagnosed early, the 5-year survival rate is 92%,2 yet 23% of CRCs are diagnosed at an advanced stage3 in the United Kingdom with a 5-year survival rate of 10%.2 Early CRC has symptoms that are shared with common benign conditions.4 Colonoscopy capacity is limited, and referring all symptomatic patients for colonoscopy would overwhelm available resources. An intermediate triage test to identify patients at risk of CRC could streamline referral pathways.