医学
冲程(发动机)
侧支循环
逻辑回归
接收机工作特性
内科学
单变量分析
曲线下面积
队列
前瞻性队列研究
试验预测值
急性中风
回顾性队列研究
多元分析
心脏病学
组织纤溶酶原激活剂
机械工程
工程类
作者
Jiän Zhang,Juan Liu,Shijian Chen,Huagang Li,Jun Luo,Youlin Wu,Peiyang Zhou,Wenguo Huang,Yue Wan,Tao Qiu,Renliang Meng,Wenjie Zi,Shengnan Shi,Deyan Kong,Yueling Zhang,Yuqi Peng,Shudong Liu,Zhijian Liang
标识
DOI:10.1016/j.clineuro.2022.107184
摘要
This study aimed to develop a score to predict the risk for symptomatic intracranial haemorrhage (sICH) associated with endovascular treatment (EVT) in patients with acute ischaemic stroke caused by large vessel occlusions (LVOs) in the anterior circulation.Between January 2017 and December 2019, acute stroke patients with anterior circulation occlusion and EVT were retrospectively enroled from 11 comprehensive stroke centres in China. Univariate analyses were performed to compare the factors in patients with or without sICH. The predictive value of parameters associated with sICH was evaluated with multivariate logistic regression, and the score was developed according to the magnitude of regression coefficients. We performed external validation in a retrospective stroke registry of EVT for acute anterior circulation ischaemic stroke in 21 comprehensive stroke centres across 10 provinces in China (ACTUAL).Of the 433 patients, 70 (16.2%) patients had sICH. The preoperative predictive factors of sICH were poor collateral circulation, low baseline ASPECTS, cardioembolic stroke and high serum glucose. Using the OR of preoperative predictive factors (collateral circulation status, baseline ASPECTS, TOAST type and serum glucose) in the multivariable model, we derived the ACTS score. In the derivation cohort, the area under the ROC curve (AUC) was 0.797; in the validation cohort, it was 0.727.The ACTS score provides a quick and easy-to-perform scale to predict the risk of sICH in acute anterior circulation stroke patients treated with EVT. This score should be further examined and improved in future prospective studies to increase its precision and applicability before it can be recommended to make clinical decisions regarding the performance of EVT.
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