生物
干扰素
免疫系统
先天免疫系统
病毒学
基因敲除
转录组
胚胎
基因
病毒
免疫
基因表达
细胞生物学
微生物学
免疫学
遗传学
作者
Xiaolan Hou,Lizhen Wang,Riteng Zhang,Gen Liu,Ting Wang,Bo Wen,Wen‐Chi L. Chang,Song Han,Jinjie Han,Junyang Fang,Xuefeng Qi,Jingyu Wang
标识
DOI:10.1016/j.psj.2024.103741
摘要
Fowl adenovirus serotype 4 (FAdV-4) infections result in substantial economic losses in the poultry industry. Recent findings have revealed that FAdV-4 significantly suppresses the host immune response upon infection; however, the specific viral and host factors contributing to this immunomodulatory activity remain poorly characterized. Moreover, diverse cell types exhibit differential immune responses to FAdV-4 infection. To elucidate cell-specific host responses, we performed transcriptomic analysis of FAdV-4 infected leghorn male hepatocellular (LMH) and chicken embryo fibroblast (CEF) cells. Although FAdV-4 replicated more efficiently in LMH cells, it provoked limited interferon-stimulated gene induction. In contrast, FAdV-4 infection triggered robust antiviral responses in CEF cells, including upregulation of cytosolic DNA sensing and interferon-stimulated genes. Knockdown of key cytosolic DNA sensing molecules enhanced FAdV-4 replication in LMH cells while reducing interferon-stimulated gene expression. Our findings reveal cell-specific virus-host interactions that provide insight into FAdV-4 pathogenesis while identifying factors that mediate antiviral immunity against FAdV-4.
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