纳米纤维
静电纺丝
聚己内酯
生物相容性
热重分析
材料科学
抗菌剂
扫描电子显微镜
化学
纳米技术
聚合物
有机化学
复合材料
冶金
作者
R. Sathya,Sangeetha Kandasamy,Agieshkumar Balakrishnapillai,Daisy Precilla,Nooruddin Thajuddin,Majid Rasool Kamli,Jamal S. M. Sabir,Sang-Yul Lee,Jung-Wan Kim,D. MubarakAli
标识
DOI:10.1016/j.ijpharm.2024.124052
摘要
Antimicrobial peptides (AMPs) are promising novel agents for targeting a wide range of pathogens. In this study, microalgal peptides derived from native microalgae were incorporated into polycaprolactone (PCL) with ƙ-Carrageenan (ƙ-C) forming nanofibers using the electrospinning method. The peptides incorporated in the nanofibers were characterized by fourier infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy (SEM), and contact angle measurement. The results showed that peptides with molecular weights < 10 kDa, when loaded into nanofibers, exhibited lower wettability. The SEM analysis revealed a thin, smooth, interconnected bead-like structures. The antimicrobial activity of the electrospun nanofibers was evaluated through disc diffusion, and minimum inhibitory activity against Escherichia coli (MTTC 443), and Staphylococcus aureus (MTTC 96), resulting in zones of inhibition of 24 ± 0.5 mm and 14 ± 0.5 mm, respectively. The in vitro biocompatibility of the synthesized nanofibers was confirmed using in HEK 293 cell lines with an increased cell viability. Interestingly, the fibers also exhibited a significant wound-healing properties when used in vitro scratch assays. In conclusion, algal peptides incorporated with PCL/ ƙ-C were found to exhibit antimicrobial and biocompatible biomaterials for wound healing applications.
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