Corneal Complications Related to Dupilumab Use

Objectives: The aim of this report is to describe atypical corneal complications associated with dupilumab use. Methods: This is a series of four cases of adult patients with infiltrative or ulcerative keratitis secondary to dupilumab use. Results: All four patients in this series were prescribed dupilumab for the treatment of atopic dermatitis and developed infiltrative or ulcerative corneal lesions. In all cases, corneal disease was successfully managed with immediate discontinuation of dupilumab and topical steroid treatment. In two cases, the patient also received antibiotic eye drops for infection precautions. Conclusions: Although dupilumab is most commonly associated with conjunctivitis, physicians should be aware of potential severe corneal complications for early identification and intervention.