The Total Synthesis and Structure Revision of Lydiamycin A

Abstract The total synthesis and structure revision of lydiamycin A is described. The recently proposed structure of lydiamycin A reported by Oh et al. was found to be incorrect by total synthesis. As our synthesis of lydiamycin F, an analog with succinic acid instead of the aliphatic acid moiety, confirmed the reported structure, we speculated structural errors in the structure of the aliphatic acid moiety. A new structure of lydiamycin A was proposed based on the structural consideration of the related natural products, matlystatins, derived from Streptomyces, and its total synthesis resulted in the achievement of the structure revision of lydiamycin A.