Unanticipated metabolic plasticity in response to chronic hypoxia

In this issue of Cell Metabolism, Midha et al. investigate the metabolic changes in mice after exposure to reduced oxygen tension for an acute or chronic duration. Their organ-specific findings may help explain physiological observations in humans living at high altitude but raise additional questions concerning pathological hypoxia after vascular damage or in cancer. In this issue of Cell Metabolism, Midha et al. investigate the metabolic changes in mice after exposure to reduced oxygen tension for an acute or chronic duration. Their organ-specific findings may help explain physiological observations in humans living at high altitude but raise additional questions concerning pathological hypoxia after vascular damage or in cancer. Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolismMidha et al.Cell MetabolismMarch 07, 2023In BriefMidha et al. show that functional adaptation to hypoxia is accompanied by organ-specific metabolic rewiring. Acute hypoxia promotes glucose uptake in most organs while reducing oxygen-consuming glucose oxidation. Chronic hypoxia promotes fatty acid metabolism in the brain, liver, and kidney while increasing glucose oxidation in the heart. Full-Text PDF