心理学
认知
心理弹性
情景记忆
队列
认知功能衰退
认知心理学
发展心理学
神经科学
疾病
医学
病理
痴呆
心理治疗师
作者
Lindsey Dobyns,Kailin Zhuang,Suzanne L. Baker,Dan M Mungas,William J. Jagust,Theresa M. Harrison
出处
期刊:Nature Aging
日期:2023-02-06
卷期号:3 (2): 229-237
被引量:4
标识
DOI:10.1038/s43587-022-00353-2
摘要
Accurately measuring resilience to preclinical Alzheimer's disease (AD) pathology is essential to understanding an important source of variability in cognitive aging. In a cohort of cognitively normal older adults (n = 123, age 76.75 ± 6.15 yr), we built a multifactorial measure of resilience which moderated the effect of AD pathology on longitudinal cognitive change. Linear residuals-based measures of resilience, along with other proxy measures (education and vocabulary), were entered into a hierarchical partial least-squares path model defining a putative consolidated resilience latent factor (model goodness of fit = 0.77). In a set of validation analyses using linear mixed models predicting longitudinal cognitive change, there was a significant three-way interaction among consolidated resilience, tau and time on episodic memory change (P = 0.001) such that higher resilience blunted the effect of tau pathology on episodic memory decline. Interactions between consolidated resilience and amyloid pathology on non-memory cognition decline suggested that resilience moderates pathology-specific effects on different cognitive domains. Dobyns et al. use latent variable modeling to derive a single, putative measure of resilience that buffered the effects of the hallmark Alzheimer's disease pathologies, tau and amyloid, on episodic memory and non-memory decline, respectively.
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