Combination of the triglyceride‐glucose index and EuroSCORE II improves the prediction of long‐term adverse outcomes in patients undergoing coronary artery bypass grafting

Abstract Aims We aimed to investigate the independent and combined association of the triglyceride‐glucose (TyG) index and EuroSCORE II with major adverse cardiovascular event (MACE) after coronary artery bypass grafting (CABG), and examine whether the addition of the TyG index improves the predictive performance of the EuroSCORE II. Materials and Methods This study included 1013 patients who underwent CABG. The primary endpoint was MACE, which was defined as the composite of all‐cause death, repeat coronary artery revascularisation, non‐fatal myocardial infarction and non‐fatal stroke. The patients were grouped by the TyG index and EuroSCORE II tertiles and the combination of these risk indicators. Results During the follow‐up, 211 individuals developed MACE. Elevated levels of the TyG index and EuroSCORE II were associated with an increased risk of MACE. The hazard ratio [95% confidence interval (CI)] was 3.66 (2.34–5.73) in patients with the highest tertile of the TyG index and EuroSCORE II. Compared with the EuroSCORE II alone, combining the TyG index with EuroSCORE II achieved a better predictive performance [C‐statistic increased 0.032, p < 0.001; continuous net reclassification improvement (NRI) (95% CI): 0.364 (0.215–0.514), p < 0.001; integrated discrimination improvement (IDI) (95% CI): 0.015 (0.007–0.023), p < 0.001, Akaike's information criteria (AIC) and Bayesian information criterion (BIC) decreased, and the likelihood ratio test, p < 0.001]. Conclusions The TyG index and EuroSCORE II are independently associated with poor prognosis. Furthermore, the TyG index is an important adjunct to the EuroSCORE II for improving risk stratification and guiding early intervention among post‐CABG patients.