Genetic Variants can Predict the Outcome of Brace Treatment in Patients With Adolescent Idiopathic Scoliosis

医学 特发性脊柱侧凸 撑杆 脊柱侧凸 结果(博弈论) 物理疗法 物理医学与康复 儿科 外科 机械工程 数学 数理经济学 工程类
作者
Zhicheng Dai,Kaixing Min,Zhichong Wu,Leilei Xu,Zhenhua Feng,Yongrong Qiu,Zezhang Zhu
出处
期刊:Spine [Lippincott Williams & Wilkins]
卷期号:50 (4): 238-242
标识
DOI:10.1097/brs.0000000000005137
摘要

Study design: A genetic case-control study. Objectives: To investigate the association between AIS progression-associated SNPs reported by GWAS studies and the effectiveness of brace treatment. Summary of background data: Bracing is the most effective conservative method to treat adolescent idiopathic scoliosis (AIS). Several factors have been reported to be associated with bracing failure in AIS patients. Genetic markers associated with AIS have potential prognostic value. Methods: A retrospective cohort of AIS patients undergoing brace treatment was enrolled in this study and divided into success and failure groups based on treatment outcome. Clinical characteristics of AIS patients were documented. Candidate SNPs were selected from previous GWAS studies of AIS, which were known to be associated with curve progression and validated across diverse populations. Genotype and allele frequencies between the success and failure groups were compared using chi-square analysis. Results: A total of 259 female AIS patients were included in this study, 30.5% of the well-braced patients had curve progression exceeding 5° and 69.5% of the patients undergo an improvement or progression of less than 5°. Allele C of rs10738445 ( BNC2 ) could significantly add to the risk of bracing failure, with odds ratio of 1.59. No significant association with bracing outcomes was found for rs12946942 ( SOX9/KCNJ2 ), rs1978060 ( TBX1 ), rs1017861 ( CHD7 ), and rs35333564 ( MIR4300HG ). Conclusions: SNP rs10738445 were significantly associated with brace treatment effectiveness. The other four SNPs were not significantly associated with the outcome of bracing. More SNPs and predictors should be included in future study to develop a more accurate predictive model for clinical application.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
勤奋紊发布了新的文献求助10
1秒前
缓慢氧化发布了新的文献求助10
1秒前
1秒前
2秒前
脑洞疼应助计蒙采纳,获得10
2秒前
科研小白发布了新的文献求助10
3秒前
3秒前
晚心完成签到,获得积分10
3秒前
今后应助lunhui采纳,获得10
4秒前
FLORA发布了新的文献求助30
4秒前
liric发布了新的文献求助10
4秒前
DONGN发布了新的文献求助10
5秒前
晚心发布了新的文献求助10
5秒前
顾矜应助任性采纳,获得30
5秒前
所所应助好心秦采纳,获得30
6秒前
称心的半邪完成签到,获得积分10
7秒前
9秒前
9秒前
一裤子灰完成签到,获得积分10
10秒前
哆啦A梦发布了新的文献求助10
10秒前
彭于晏应助Songyuxuan采纳,获得10
11秒前
NexusExplorer应助葱花鱼采纳,获得10
11秒前
星辰大海应助徐矜采纳,获得10
11秒前
rzzzy完成签到,获得积分10
14秒前
甜美罢了发布了新的文献求助10
14秒前
15秒前
16秒前
白白完成签到,获得积分10
16秒前
17秒前
脉动应助整齐的大开采纳,获得10
17秒前
ding应助琪琪七七采纳,获得10
17秒前
失眠的蓝完成签到,获得积分10
18秒前
搜集达人应助小卜采纳,获得10
18秒前
邱邱完成签到,获得积分10
19秒前
20秒前
20秒前
20秒前
淡定的火发布了新的文献求助10
21秒前
勤奋紊完成签到,获得积分10
21秒前
高分求助中
Psychopathic Traits and Quality of Prison Life 1000
Malcolm Fraser : a biography 680
Signals, Systems, and Signal Processing 610
天津市智库成果选编 600
Forced degradation and stability indicating LC method for Letrozole: A stress testing guide 500
全相对论原子结构与含时波包动力学的理论研究--清华大学 500
A Foreign Missionary on the Long March: The Unpublished Memoirs of Arnolis Hayman of the China Inland Mission 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 物理 内科学 复合材料 催化作用 物理化学 光电子学 电极 细胞生物学 基因 无机化学
热门帖子
关注 科研通微信公众号,转发送积分 6453589
求助须知:如何正确求助?哪些是违规求助? 8264841
关于积分的说明 17613845
捐赠科研通 5518950
什么是DOI,文献DOI怎么找? 2904370
邀请新用户注册赠送积分活动 1881177
关于科研通互助平台的介绍 1723685