群体感应
生化工程
合成生物学
代谢工程
生物膜
计算机科学
计算生物学
生物
细菌
工程类
生物化学
基因
遗传学
作者
Pengfei Gu,Qianqian Ma,Shuo Zhao,Gloria Juan,Changtao Li,Hao Zhou,Shuixing Jiang,Qiang Li
标识
DOI:10.1007/s11274-022-03382-6
摘要
With advantages of low substrates cost, high optical purity of end products and environmentally friendly fermentation process, microbial production of valuable chemicals grow rapidly. Compared with static microbial strain engineering strategies, such as gene deletion, overexpression and mutation, dynamic pathway regulation is a new approach that balances cellular growth and chemical production. Quorum sensing is a natural microbial communication system responsible for cell-density-related cell behaviors. Accordingly, quorum sensing systems can be employed to achieve dynamic regulation in microorganisms without the need for manual intervention or the use of chemical inducers. In this review, natural quorum sensing systems are firstly summarized. Then, recent progress in using quorum sensing circuits in the field of metabolic engineering is highlighted. The current application challenges of quorum sensing systems and future perspectives in microbial synthesis of chemicals are also discussed.Graphical abstract
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