生物
细胞生物学
细胞因子
白细胞介素15
普通伽马链
CD8型
信号转导
细胞因子受体
免疫系统
背景(考古学)
T细胞
免疫学
白细胞介素
化学
白细胞介素10
古生物学
作者
Thomas A. Waldmann,Robert Waldmann,Jian-Xin Lin,Warren J. Leonard
出处
期刊:Advances in Immunology
日期:2022-01-01
卷期号:: 103-132
被引量:1
标识
DOI:10.1016/bs.ai.2022.09.002
摘要
Interleukin-15 is a pleiotropic cytokine type I four alpha-helical bundle cytokine that along with IL-2, IL-4, IL-7, IL-9, and IL-21 shares the common cytokine receptor γ chain, γc. IL-15 is vital for the development, survival, and expansion of natural killer cells and for the development of CD8+ memory T cells. Whereas other family γc cytokines signal by directly binding to their target cells, IL-15 is distinctive in that it binds to IL-15Rα, a sushi domain containing binding protein that is expressed on a number of cell types, including monocytes and dendritic cells as well as T cells, and then is trans-presented to responding cells that express IL-2Rβ and γc. This distinctive mechanism for IL-15 relates to its role in signaling in the context of cell-cell interactions and signaling synapses. The actions of IL-15 and ways of manipulating its actions to potential therapeutic benefit are discussed.
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