清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Comparative accuracy of biomarkers for the prediction of hospital-acquired acute kidney injury: a systematic review and meta-analysis

医学 生物标志物 内科学 诊断优势比 急性肾损伤 优势比 荟萃分析 肌酐 科克伦图书馆 泌尿系统 生物化学 化学
作者
Heng‐Chih Pan,Shaoyu Yang,Terry Ting-Yu Chiou,Chih‐Chung Shiao,Che‐Hsiung Wu,Chun-Te Huang,Tsai‐Jung Wang,Jui-Yi Chen,Hung-Wei Liao,Sheng-Yin Chen,Tao‐Min Huang,Yu‐Cih Yang,Hugo You-Hsien Lin,Ming‐Jen Chan,Chiao‐Yin Sun,Yih‐Ting Chen,Yung‐Chang Chen,Vin‐Cent Wu
出处
期刊:Critical Care [Springer Nature]
卷期号:26 (1) 被引量:17
标识
DOI:10.1186/s13054-022-04223-6
摘要

Several biomarkers have been proposed to predict the occurrence of acute kidney injury (AKI); however, their efficacy varies between different trials. The aim of this study was to compare the predictive performance of different candidate biomarkers for AKI.In this systematic review, we searched PubMed, Medline, Embase, and the Cochrane Library for papers published up to August 15, 2022. We selected all studies of adults (> 18 years) that reported the predictive performance of damage biomarkers (neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), liver-type fatty acid-binding protein (L-FABP)), inflammatory biomarker (interleukin-18 (IL-18)), and stress biomarker (tissue inhibitor of metalloproteinases-2 × insulin-like growth factor-binding protein-7 (TIMP-2 × IGFBP-7)) for the occurrence of AKI. We performed pairwise meta-analyses to calculate odds ratios (ORs) and 95% confidence intervals (CIs) individually. Hierarchical summary receiver operating characteristic curves (HSROCs) were used to summarize the pooled test performance, and the Grading of Recommendations, Assessment, Development and Evaluations criteria were used to appraise the quality of evidence.We identified 242 published relevant studies from 1,803 screened abstracts, of which 110 studies with 38,725 patients were included in this meta-analysis. Urinary NGAL/creatinine (diagnostic odds ratio [DOR] 16.2, 95% CI 10.1-25.9), urinary NGAL (DOR 13.8, 95% CI 10.2-18.8), and serum NGAL (DOR 12.6, 95% CI 9.3-17.3) had the best diagnostic accuracy for the risk of AKI. In subgroup analyses, urinary NGAL, urinary NGAL/creatinine, and serum NGAL had better diagnostic accuracy for AKI than urinary IL-18 in non-critically ill patients. However, all of the biomarkers had similar diagnostic accuracy in critically ill patients. In the setting of medical and non-sepsis patients, urinary NGAL had better predictive performance than urinary IL-18, urinary L-FABP, and urinary TIMP-2 × IGFBP-7: 0.3. In the surgical patients, urinary NGAL/creatinine and urinary KIM-1 had the best diagnostic accuracy. The HSROC values of urinary NGAL/creatinine, urinary NGAL, and serum NGAL were 91.4%, 85.2%, and 84.7%, respectively.Biomarkers containing NGAL had the best predictive accuracy for the occurrence of AKI, regardless of whether or not the values were adjusted by urinary creatinine, and especially in medically treated patients. However, the predictive performance of urinary NGAL was limited in surgical patients, and urinary NGAL/creatinine seemed to be the most accurate biomarkers in these patients. All of the biomarkers had similar predictive performance in critically ill patients. Trial registration CRD42020207883 , October 06, 2020.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
俊逸的白梦完成签到 ,获得积分10
刚刚
橘子海完成签到 ,获得积分10
5秒前
Tianju完成签到,获得积分10
10秒前
研友_Lmg1gZ完成签到,获得积分10
10秒前
huazhangchina完成签到 ,获得积分10
32秒前
高雯完成签到,获得积分10
34秒前
芝诺的乌龟完成签到 ,获得积分0
37秒前
张颖完成签到 ,获得积分10
45秒前
欢呼的茗茗完成签到 ,获得积分10
52秒前
丹妮完成签到 ,获得积分10
53秒前
59秒前
longlonglong完成签到,获得积分10
1分钟前
1分钟前
荔枝波波加油完成签到 ,获得积分10
1分钟前
Danny完成签到 ,获得积分10
1分钟前
Young完成签到 ,获得积分10
1分钟前
郑先生完成签到 ,获得积分10
1分钟前
郑志凡完成签到 ,获得积分10
1分钟前
wanci应助科研通管家采纳,获得10
2分钟前
啥也不是完成签到,获得积分10
2分钟前
双眼皮跳蚤完成签到,获得积分10
2分钟前
kehe!完成签到 ,获得积分0
2分钟前
霸霸斌完成签到 ,获得积分10
2分钟前
gmc完成签到 ,获得积分10
2分钟前
谷子完成签到 ,获得积分10
2分钟前
数乱了梨花完成签到 ,获得积分10
3分钟前
寒战完成签到 ,获得积分10
3分钟前
沐浠完成签到 ,获得积分10
3分钟前
salty完成签到 ,获得积分10
3分钟前
桐桐应助123采纳,获得10
3分钟前
Shandongdaxiu完成签到 ,获得积分10
3分钟前
HCKACECE完成签到 ,获得积分10
3分钟前
Vicky完成签到 ,获得积分10
3分钟前
3分钟前
丰富的绮山完成签到,获得积分10
3分钟前
烟花应助科研通管家采纳,获得30
4分钟前
Akim应助科研通管家采纳,获得30
4分钟前
123发布了新的文献求助10
4分钟前
段采萱完成签到 ,获得积分10
4分钟前
Ava应助123采纳,获得30
4分钟前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3052644
求助须知:如何正确求助?哪些是违规求助? 2709863
关于积分的说明 7418252
捐赠科研通 2354395
什么是DOI,文献DOI怎么找? 1246007
科研通“疑难数据库(出版商)”最低求助积分说明 605951
版权声明 595921