Anti-Aging Effects of Polysaccharides Derived from Amauroderma rugosum (Agaricomycetes) Aqueous Extract on Keratinocytes

There is little documentation currently on the pharmacological activity and therapeutic value of Amauroderma rugosum (AR). However, the antioxidant and anti-inflammatory effects of AR aqueous extracts on keratinocytes have been reported. This study has aimed to investigate whether the antioxidant and anti-inflammatory properties of AR are related to its polysaccharides, and whether the polysaccharides of AR (ARP) have the potential to inhibit enzymes related to skin aging. The results showed that ARP was nontoxic. It displayed direct antioxidant capacity and inhibited the release of chemokine monocyte chemoattractant protein-1 in HaCaT cells stimulated by tumor necrosis factor (TN-F)-α- and interferon (IFN)-γ. ARP also exhibits anti-enzymatic activity against collagenase, elastase, hyaluronidase, and tyrosinase. These findings underscore the potential for integrating ARP into novel nature-based skin care formulations.