医学
前列腺癌
前列腺
淋巴结
阶段(地层学)
病变
转移
原发性肿瘤
癌症
病理
肿瘤科
局限性疾病
内科学
生物
古生物学
作者
Jeroen Kneppers,Oscar Krijgsman,Monique Melis,Jeroen de Jong,Daniel S. Peeper,Elise M. Bekers,Henk G. van der Poel,Wilbert Zwart,Andries M. Bergman
出处
期刊:JCI insight
[American Society for Clinical Investigation]
日期:2019-01-24
卷期号:4 (2)
被引量:28
标识
DOI:10.1172/jci.insight.124756
摘要
Primary prostate cancer lesions are clonally heterogeneous and often arise independently. In contrast, metastases were reported to share a monoclonal background. Because prostate cancer mortality is the consequence of distant metastases, prevention of metastatic outgrowth by primary tumor ablation is the main focus of treatment for localized disease. Focal therapy is targeted ablation of the primary index lesion, but it is unclear whether remaining primary lesions metastasize at a later stage. In this study, we compared copy number aberration profiles of primary prostate cancer lesions with matching pelvic lymph node metastases of 30 patients to establish clonality between a lymph node metastasis and multiple primary lesions within the same patient. Interestingly, in 23.3% of the cases, the regional metastasis was not clonally linked to the index primary lesion. These findings suggest that focal ablation of only the index lesion is potentially an undertreatment of a significant proportion of prostate cancer patients.
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