Efficacy and safety of tranexamic acid in obstetric hemorrhage: a systematic review and meta-analysis. Eficacia y seguridad del ácido tranexámico en la hemorragia obstétrica: revisión sistemática y meta-análisis.

This systematic review and meta-analysis evaluates the efficacy and safety of tranexamic acid (TXA) in obstetric hemorrhage, including postpartum hemorrhage (PPH) and antepartum hemorrhage. Primary outcomes include maternal mortality and total blood loss (mL). Secondary outcomes include emergency hysterectomy rate, red blood cell transfusion requirement, additional surgical interventions, time to hemostasis, thromboembolic events, and ICU length of stay. Databases searched: PubMed/MEDLINE, Embase, CENTRAL, LILACS, and ClinicalTrials.gov (2010–2024). Statistical analysis: DerSimonian-Laird random-effects model. Reported following PRISMA 2020 guidelines.