Enantioselective synthesis of aziridine-fused polycyclic architectures via a catalytic asymmetric aza-Darzens reaction and reductive cyclization

A novel protocol to access an aziridine-fused heterotricyclo[4.3.0.0 2,9 ]decane framework was developed via a CPA-catalyzed asymmetric aza-Darzens reaction of quinoxalin-2(1 H )-ones with diazoacetates, followed by LiAlH 4 -mediated reductive cyclization.