Bioresorbable Piezo‐Triboelectric Patch Enabled Bioelectric Stimulation for Accelerated Wound Healing

ABSTRACT Achieving bioresorbable electroactive dressings with self‐powered electrical stimulation capability for wound management remains a formidable challenge due to the scarcity of biomaterials that could offer a strong ability of harvest physio‐mechanical energy. Here, we present a fully bioresorbable polyvinyl alcohol/glycine‐Ca 2+ piezo‐triboelectric nanogenerator (PGC‐PTNG) patch, with integrated lateral electrodes to generate a biomimetic endogenous electric field across the wound site to assist healing. The patch achieves open‐circuit voltages up to 55.6 V under physio‐mechanical loading, and 2–3 V from moving Sprague‐Dawley rats. Calcium ions in PGC play dual roles: they induce the formation of electroactive β‐phase in glycine and increase the surface potential of the PGC layer, thereby enhancing the electrical performance of the PGC‐PTNG; and they are released during degradation as bioactive mediators that facilitate angiogenesis and extracellular matrix remodeling. Results demonstrate that the patch effectively promotes fibroblast activation, collagen deposition, and vascular network formation, leading to accelerated wound closure (∼98.5% vs. ∼72.3%) and markedly reduced residual wound length (∼0.93 vs. ∼5.85 mm). Collectively, this self‐powered patch addresses critical shortcomings of current electroactive dressings, enabling safe, and effective wound management and tissue regeneration.