心理学
静息状态功能磁共振成像
痴呆
蒙特利尔认知评估
人口
神经心理学
认知
神经科学
阿尔茨海默病
功率图分析
医学
认知障碍
图形
疾病
内科学
计算机科学
环境卫生
理论计算机科学
作者
Yuan Luo,Tongtong Sun,Chunchao Ma,Xianchang Zhang,Yong Ji,Xiuwei Fu,Hongbo Ni
出处
期刊:Neuroscience
[Elsevier]
日期:2021-01-01
卷期号:452: 192-207
被引量:20
标识
DOI:10.1016/j.neuroscience.2020.10.023
摘要
This study aimed to investigate the alterations in brain networks in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) based on a population-specific brain template. Previous studies on AD brain networks using graph theory rarely adopted brain templates specific for certain ethnicities. In this study, patients were divided into 3 groups: AD (n = 24), MCI (n = 27), and healthy controls (HCs, n = 33), and all of the subjects are Chinese. Functional brain networks were constructed for each group based on a Chinese brain template using resting-state functional magnetic resonance imaging (rs-fMRI) data; several graph metrics were calculated. Graph metrics with significant differences after false discovery rate (FDR) correction were analyzed with respect to correlations with four neuropsychological test scores: Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Activities of Daily Living (ADL), and Clinical Dementia Rating (CDR), which assessed the subjects’ cognitive functions and ability to engage in ADL. Graph metrics including assortativity coefficient, nodal degree centrality, nodal clustering coefficient, nodal efficiency, and nodal local efficiency of the frontal gyrus and cerebellum were significantly altered in AD and MCI compared with HC. Several graph metrics were significantly correlated with cognitive function and the ability to engage in daily activities. The findings suggest that altered graph metrics in the frontal gyrus may reflect brain plasticity, and that patients with MCI may have unique graph metric alterations in the cerebellum. Future graph analysis studies on functional brain networks in AD and MCI based on population-specific brain atlases for particular ethnicities may prove valuable.
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