抗菌剂
广谱
自愈水凝胶
细菌
药物输送
生物分子
生物利用度
化学
药品
纳米技术
细菌细胞结构
抗菌肽
膜
生物物理学
组合化学
材料科学
生物化学
生物
药理学
有机化学
遗传学
作者
Jingwen Song,Chengqian Yuan,Tifeng Jiao,Ronge Xing,Xuehai Yan,Dave J. Adams,Xuehai Yan
出处
期刊:Small
[Wiley]
日期:2020-01-29
卷期号:16 (8)
被引量:199
标识
DOI:10.1002/smll.201907309
摘要
Abstract There is a real need for new antibiotics against self‐evolving bacteria. One option is to use biofriendly broad‐spectrum and mechanically tunable antimicrobial hydrogels that can combat multidrug‐resistant microbes. Whilst appealing, there are currently limited options. Herein, broad‐spectrum antimicrobial biometallohydrogels based on the self‐assembly and local mineralization of Ag + ‐coordinated Fmoc‐amino acids are reported. Such biometallohydrogels have the advantages of localized delivery and sustained release, reduced drug dosage and toxicity yet improved bioavailability, prolonged drug effect, and tunable mechanical strength. Furthermore, they can directly interact with the cell walls and membrane, resulting in the detachment of the plasma membrane and leakage of the cytoplasm. This leads to cell death, triggering a significant antibacterial effect against both Gram‐negative ( Escherichia coli ) and Gram‐positive ( Staphylococcus aureus ) bacteria in cells and mice. This study paves the way for developing a multifunctional integration platform based on simple biomolecules coordinated self‐assembly toward a broad range of biomedical applications.
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