化学
细菌
单线态氧
聚集诱导发射
革兰氏阳性菌
荧光
体外
生物物理学
活性氧
细菌细胞结构
克
生物化学
氧气
有机化学
物理
抗生素
生物
量子力学
遗传学
作者
Miaomiao Kang,Chengcheng Zhou,Shuangmei Wu,Bingran Yu,Zhijun Zhang,Nan Song,Michelle M. S. Lee,Wenhan Xu,Fu‐Jian Xu,Dong Wang,Lei Wang,Ben Zhong Tang
摘要
Bacterial infectious diseases, especially those caused by Gram-positive bacteria, have been seriously threatening human health. Preparation of a multifunctional system bearing both rapid bacterial differentiation and effective antibacterial effects is highly in demand, but remains a severe challenge. Herein, we rationally designed and successfully developed a sequence of aggregation-induced emission luminogens (AIEgens) with orderly enhanced D–A strength. Evaluation of structure–function relationships reveals that AIEgens having intrinsic positive charge and proper ClogP value are able to stain Gram-positive bacteria. Meanwhile, one of the presented AIEgens (TTPy) can generate reactive oxygen species (ROS) in extraordinarily high efficiency under white light irradiation due to the smaller singlet–triplet energy gap. Thanks to the NIR emission, excellent specificity to Gram-positive bacteria, and effective ROS generation efficiency, TTPy has been proved to perform well in selective photodynamic killing of Gram-positive bacteria in vitro, such as S. aureus and S. epidermidis, even in S. aureus-infected rat wounds.
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