A tale on rabbit ears and pan-handles, the rings that rule all

It seems rather remarkable that an off-hand observation made decades ago on the existence of circular RNA molecules, is increasingly capturing investigators’ interests [1]. In this article in EBioMedicine, Zhang and colleagues turned their attention to the effect of a well-known and frequently described circular RNA (circRNA) derived from the HIPK3 gene (circHIPK3) on oxaliplatin-resistance in colorectal cancer [2].