粪便
小肠结肠炎
粪钙保护素
结肠炎
溃疡性结肠炎
置信区间
接收机工作特性
作者
Yangming Qu,Wei Xu,Jun Han,Wenli Zhou,Hui Wu
标识
DOI:10.1016/j.earlhumdev.2020.105170
摘要
Abstract Background and objectives Necrotizing enterocolitis is a common gastrointestinal disease in newborns, especially in preterm infants. Our study analyzed the value of fecal calprotectin as a biomarker in the diagnosis of NEC based on previous studies that have confirmed elevated calprotectin levels in NEC patients. Method We searched several databases including PubMed, Medline, Web of Science and Cochrane Library to identify studies of humans investigating the performance characteristics of fecal calprotectin for the diagnosis of NEC. The quality of included studies was assessed by RevMan5 software (QUADAS-2). The sensitivity, specificity and other measurements of accuracy of fecal calprotectin were pooled using Meta-DiSc software. Result A total 10 studies with 568 patients included in our meta-analysis. The pooled sensitivity, specificity, diagnostic odds ratio (DOR) and AUC were: 0.86 (95%CI: 0.80–0.91), 0.79 (95%CI: 0.75–0.83), 34.78 (95% CI: 15.30 to 79.07) and 0.92. The pooled sensitivity, specificity, DOR and AUC of subgroup analysis were: 0.85 (95%CI: 0.79–0.90), 0.89 (95%CI: 0.85–0.92), 41.03 (95% CI: 16.87 to 99.78) and 0.92 for nine studies using ELISA; 0.85 (95%CI: 0.79–0.90), 0.89 (95%CI: 0.85–0.92), 42.08 (95% CI: 18.44 to 96.04) and 0.93 for six prospective studies; 0.91 (95%CI: 0.82–0.97), 0.93 (95%CI: 0.88–0.96), 69.51 (95% CI: 17.67 to 273.40) and 0.95 for four studies of preterm infants. 0.86 (95%CI: 0.77–0.92), 0.94 (95%CI: 0.90–0.97), 53.23 (95% CI: 15.68 to 180.73) and 0.94 five studies that defined NEC as stage II or above. Conclusion Fecal calprotectin is a promising biomarker with high diagnostic value in neonatal, especially in premature infants.
科研通智能强力驱动
Strongly Powered by AbleSci AI