化学
废止
甲酰胺
苯乙酮
氧化磷酸化
芳基
药物化学
组合化学
立体化学
有机化学
催化作用
生物化学
烷基
作者
Santosh D. Jadhav,Anand Singh
出处
期刊:Organic Letters
[American Chemical Society]
日期:2017-10-05
卷期号:19 (20): 5673-5676
被引量:86
标识
DOI:10.1021/acs.orglett.7b02838
摘要
An efficient strategy toward 4-arylquinolines and 4-arylpyrimidines from readily available precursors is described. Oxidative annulation promoted by K2S2O8 involving anilines, aryl ketones, and DMSO as a methine (═CH−) equivalent leads to 4-arylquinolines via a cascade that entails generation of a sulfenium ion, subsequent C–N and C–C bond formations, and cyclization. The application of this strategy to the activation of acetophenone–formamide conjugates toward the synthesis of 4-arylpyrimidines is also described.
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