小RNA
医学
癌症
生物标志物
内科学
肿瘤科
癌症研究
生物信息学
作者
Edoardo Virgilio,Enrico Giarnieri,Maria Rosaria Giovagnoli,Monica Montagnini,Antonella Proietti,Rosaria D'Urso,Paolo Mercantini,Genoveffa Balducci,Marco Cavallini
出处
期刊:Anticancer Research
[Anticancer Research USA Inc.]
日期:2018-02-01
卷期号:38 (2): 613-616
被引量:24
标识
DOI:10.21873/anticanres.12265
摘要
Background/aim To date, the combination of gastroscopy with biopsy remains the only test validated for screening gastric cancer (GC). Currently, analysis of circulating microRNAs (miRNAs or miRs) is providing interesting information on GC prognosis, but since these molecules are shared by several types of cancer, its clinical use could be questionable and difficult. MicroRNAs in gastric juice (GJ) could represent a cogent alternative to screening GC by biopsy. Materials and methods We investigated the pertinent literature dealing with GC GJ microRNAs through four popular search engines (PubMed, Science Direct, Scopus and Google Scholar). Results As of 2017, only four studies had been published and were all from Chinese experience. MiR-421, miR-129, miR-21, miR-106a and miR-133a were the five molecules studied in the GJ of the enrolled patients. Conclusion The GJ miRNA test is reliable and reproducible. The discussed GJ miRNAs appear to be new potential biomarkers for the screening of GC.
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