生物
增强子
基因组
长非编码RNA
转录组
计算生物学
抄写(语言学)
功能(生物学)
非编码DNA
基因表达调控
核糖核酸
遗传学
发起人
非编码RNA
转录因子
基因
基因表达
哲学
语言学
作者
Florian Kopp,Joshua T. Mendell
出处
期刊:Cell
[Elsevier]
日期:2018-01-01
卷期号:172 (3): 393-407
被引量:2539
标识
DOI:10.1016/j.cell.2018.01.011
摘要
Over the last decade, it has been increasingly demonstrated that the genomes of many species are pervasively transcribed, resulting in the production of numerous long noncoding RNAs (lncRNAs). At the same time, it is now appreciated that many types of DNA regulatory elements, such as enhancers and promoters, regularly initiate bi-directional transcription. Thus, discerning functional noncoding transcripts from a vast transcriptome is a paramount priority, and challenge, for the lncRNA field. In this review, we aim to provide a conceptual and experimental framework for classifying and elucidating lncRNA function. We categorize lncRNA loci into those that regulate gene expression in cis versus those that perform functions in trans and propose an experimental approach to dissect lncRNA activity based on these classifications. These strategies to further understand lncRNAs promise to reveal new and unanticipated biology with great potential to advance our understanding of normal physiology and disease.
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