菠萝蛋白酶
阿纳纳斯
纳米技术
化学
蛋白水解酶
纳米颗粒
溶解度
生化工程
蛋白酶
生物化学
酶
材料科学
生物
工程类
有机化学
园艺
作者
Janaína Artem Ataide,Eloah Favero Gérios,Priscila Gava Mazzola,Eliana B. Souto
标识
DOI:10.1016/j.cis.2018.03.006
摘要
Stem bromelain is a common available cysteine protease derived from pineapple (Ananas comosus L.). Bromelain finds widespread applications in several areas, such as medicine, health, food, and cosmetics, and its strong proteolytic activity supports its future application in many additional fields. However, most proteins and/or enzymes are fragile, leading to important considerations about increase storage and operational stability to enable their practical application. In this scenario, the use of nanoparticles to deliver proteins is increasing exponentially, given that these systems are capable of enhance active's stability, solubility and permeability, and decrease toxicity. In the pharmaceutical nanotechnology field, bromelain has played different roles and thus this paper aims to review the available literature for the use of nanoparticles and bromelain.
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