Facile Transformation of Nitriles into Thioamides: Application to C ‐Glycosyl Nitrile Derivatives

Abstract An effective reaction condition for the rapid transformation of nitrile derivatives into thioamide derivatives has been developed by the treatment with a combination of carbon disulfide and sodium sulfide. The reaction condition is equally effective for the transformation of alkyl, aryl nitriles. C ‐Glycosyl nitriles also furnished C‐glycosyl thioamide derivatives in satisfactory yield under the reported reaction condition. The reaction condition is simple, high yielding and suitable for scaled up.