[Research progress on minimally invasive and non-invasive blood glucose detection methods].

Blood glucose monitoring has become the weakest point in the overall management of diabetes in China. Long-term monitoring of blood glucose levels in diabetic patients has become an important means of controlling the development of diabetes and its complications, so that technological innovations in blood glucose testing methods have far-reaching implications for accurate blood glucose testing. This article discusses the basic principles of minimally invasive and non-invasive blood glucose testing assays, including urine glucose assays, tear assays, methods of extravasation of tissue fluid, and optical detection methods, etc., focuses on the advantages of minimally invasive and non-invasive blood glucose testing methods and the latest relevant results, and summarizes the current problems of various testing methods and prospects for future development trends.血糖检测已成为我国糖尿病综合管理中最薄弱的环节，对糖尿病患者的血糖水平进行长期监测是控制糖尿病及其并发症发展的重要手段，血糖检测方法的技术革新对实现血糖精准检测有着深远意义。本文论述了微创及无创血糖检测方法包括尿糖检测法、泪液检测法、组织液外渗法以及光学检测等方法的基本原理，重点分析了微创及无创血糖检测方法的优势及最新成果，归纳总结了各类检测方法目前存在的问题并对未来发展趋势进行展望。.