过氧化氢
谷胱甘肽
阿霉素
羟基自由基
纳米载体
铜
材料科学
生物物理学
组合化学
化学
生物化学
化疗
有机化学
激进的
生物
纳米技术
纳米颗粒
外科
医学
酶
作者
Jia Ren,Xiaorui Jiao,Mahmood Hassan Akhtar,Muhammad Azhar Hayat Nawaz,Na Yang,Chang Liu,Wen Xu,Li Y,Ning Liu,Cong Yu
标识
DOI:10.1016/j.colcom.2023.100739
摘要
Development of efficient and specialized anti-cancer agent is highly desirable for both basic and clinical research. Herein, a multifunctional organosilica nanoagent (MOCL-DOX) loaded with copper ion, arginine, and doxorubicin was designed and prepared. Copper ion (Cu2+) and arginine (LA) were doped into the S-S bond-containing degradable organosilica nanocarrier as functional components. S-S bonds were broken under excessive glutathione (GSH) conditions when the nanoagent reached the tumor sites. Simultaneously Cu2+ was released, reduced by GSH to Cu+, and Cu+ selectively converted hydrogen peroxide (H2O2) to hydroxyl radical (•OH) by Fenton-like reaction which caused extensive cellular oxidation and even apoptosis. Tumor cell viability and growth were inhibited to a great extent by the combination of CDT and chemotherapy with minimal normal cells toxicity. Thus, the MOCL-DOX nanoagent demonstrates as a novel paradigm for the fabrication of Fenton's nanoagent for efficient cancer therapy with minimal side effects.
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