化学
对映选择合成
烷基化
恶唑啉
位阻效应
有机化学
胺气处理
劈理(地质)
反应性(心理学)
组合化学
催化作用
病理
工程类
岩土工程
医学
替代医学
断裂(地质)
作者
Maoyu Shang,Yueming Cai
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2022-09-21
卷期号:34 (08): 875-881
标识
DOI:10.1055/s-0042-1752337
摘要
Abstract We reported a nickel-catalyzed enantioconvergent deaminative alkylation of α-amino acid derivatives with unactivated olefins, providing an efficient and convenient access to a range of α-enantioenriched amides. This method represents the first example of enantioselective deaminative functionalization with racemic amine precursors and features in mild conditions and broad substrate scope. New sterically encumbered bis(oxazoline) ligand was developed to improve both reactivity and enantioselectivity, which is key to the success of this reaction.
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