高脂血症
肠道菌群
拟杆菌
微生物群
生物
炎症
脂质代谢
内分泌学
血脂谱
生物化学
化学
药理学
免疫学
胆固醇
生物信息学
糖尿病
细菌
遗传学
作者
Mingchao Xu,Ruiting Lan,Lei Qiao,Xiaoying Lin,Dalong Hu,Suping Zhang,Jing Yang,Jia-Rong Zhou,Zhihong Ren,Xianping Li,Guoxing Liu,Liyun Liu,Jianguo Xu
标识
DOI:10.1128/spectrum.02517-22
摘要
As a core microbe of the human gut ecosystem, Bacteroides vulgatus has been linked to multiple aspects of metabolic disorders in a collection of associative studies, which, while indicative, warrants more direct experimental evidence to verify. In this study, we experimentally demonstrated that oral administration of B. vulgatus Bv46 ameliorated the serum lipid profile and systemic inflammation of high-fat diet-induced hyperlipidemic rats in a microbiome-regulated manner, which appears to be associated with changes of bile acid metabolism, short-chain fatty acid biosynthesis, and serum metabolomic profile.
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