Weight and Health — Pathophysiology and Therapies

In this instructional video, Drs. Louis Aronne, Ania Jastreboff, and Sriram Machineni discuss the pathophysiology of weight and explore the risks and benefits of new, effective medical therapies for weight loss. This video delves into the contributions of weight-regulating pathways, genetics, and the current societal environment that influences weight gain. It also explores the negative impacts of weight bias and stigma and discusses surgical and medical treatments for obesity, including the promising new medications tirzepatide and semaglutide. This video draws from two Original Articles published in the Journal — one by Jastreboff et al. (Tirzepatide Once Weekly for the Treatment of Obesity, in the July 21, 2022, issue) and the other by Wilding et al. (Once-Weekly Semaglutide in Adults with Overweight or Obesity, in the March 18, 2021, issue).