Leptomeningeal metastasis in patients with non–small cell lung cancer after stereotactic radiosurgery for brain metastasis

This study is the first to evaluate the risk factors for LM in a relatively large cohort of patients with NSCLC after SRS. In patients with BMs harboring risk factors for subsequent LM, such as initial tumor volume and number of metastatic lesions, aggressive therapies with high CNS penetrating ability should be considered.