(+)-纳洛酮
海洛因
医学
萧条(经济学)
减少危害
类阿片
急诊科
药理学
麻醉
药品
精神科
内科学
家庭医学
受体
经济
宏观经济学
人类免疫缺陷病毒(HIV)
作者
Jennifer Schumann,Rebekka Syrjanen,K Alford,S Mashetty,Jared W Castle,Joe‐Anthony Rotella,Jacqueline Maplesden,Shaun L Greene
摘要
Abstract Benzimidazole synthetic opioids are highly potent μ-opioid receptor agonists with heroin-like effects, including dose-dependent respiratory depression and a high risk of abuse and toxicity. Benzimidazoles were first detected in 2019 in Europe and Canada, with analytical confirmation of etodesnitazene, protonitazene and butonitazene in 2021. We report the first detections of these compounds in Australia, in two patients presenting with drug toxicity to Emergency Departments (EDs) in the state of Victoria. Case 1 was a female in her 20s who rectally administered etodesnitazene and was found unconscious with respiratory depression and hypotension. Case 2 was a female in her 30s who presented to the ED in a sedated state after taking a formulation of protonitazene that also contained butonitazene, in addition to methylamphetamine. She responded positively to naloxone. Novel synthetic opioids were used with prior experience of the formulations purchased; however, the unpredictability of their effects was demonstrated by the acute toxicity experienced with this occasion of use. Toxicosurveillance of ED presentations with analytical confirmation of drugs is crucial in identifying emerging drugs in the community and informing harm reduction strategies.
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