A nitric oxide-boosting molecular agent to enhance mild-temperature photothermal therapy

A nitric oxide (NO)-boosting molecular agent (CyHU) was developed for enhanced mild-temperature photothermal therapy (MPTT). This photothermal agent can specifically target mitochondria and efficiently produce NO, inhibiting adenosine triphosphate-dependent heat shock proteins, reversing tumor heat tolerance and ultimately achieving MPTT of cancer cells.