Hybrid Spike-Facilitated Capture and Biofilm Destruction Co-Enhances Ultrasound-Mediated Bactericidal Therapy

-infected mice, exhibiting superior therapeutic efficacy. Cell viability assays and histopathological evaluations confirmed excellent biosafety at both cellular and organismal levels. This work establishes a bioinspired material design paradigm for targeted antimicrobial strategies with minimized resistance risks and microbiome preservation.