Pd‐Catalyzed Synthesis of Arylacetyl Thioesters from Benzyl Chlorides and Thioformates

Thioesters are vital synthons in organic synthesis and biological processes, yet their synthesis often faces challenges such as the use of toxic CO, malodorous thiophenols, and restricted substrate scope. To address these challenges, this study develops a thioester transfer strategy using thioformates as both sulfur and carbonyl sources, which enables the thiocarbonylation of benzyl chlorides. This approach facilitates the successful coupling of thioformates with benzyl chloride, providing efficient access to diverse thioesters. This advancement broadens the substrate scope and enhances the practicality of thioester synthesis in organic chemistry.