Synthesis of Substituted 3‐Allyl‐1‐methylindolin‐2‐ones by Palladium‐Catalyzed Cyclization of N‐(2‐Iodophenyl)‐N‐methylbicyclo[1.1.0]butane‐1‐carboxamides

As a novel class of reactive electrophiles, bicyclo[1.1.0]butanes (BCB) remain relatively underexplored. Herein, a palladium‐catalyzed reaction of bicyclo[1.1.0]butanes is disclosed that provides a variety of 3‐allylindolin‐2‐ones in moderate‐to‐excellent yields with very good functional group tolerance. This protocol features mild reaction conditions and broad substrate scope.