Pharmacological Applications of Iron Doped Titanium Oxide (Fe/TiO2) Nanoparticles Derived from Beta vulgaris Leaf Extract

Objectives: To evaluate the structural, morphological and pharmacological application of green synthesized iron doped titanium oxide nanoparticles derived from Beta vulgaris leaves extract. Methods: A green synthesis of Fe doped TiO2 a nanoparticle (Fe/TiO2) was achieved using aqueous extract of Beta vulgaris leaves. The obtained Fe/TiO2 was categorized by analytical techniques including UV, FTIR, XRD, SEM, EDS and TEM. Antibacterial and antifungal activities were analyzed by PDA agar disc diffusion method, while the anticancer studies were carried out using MCF-7 cell-line by MTT assay method. Findings: The FTIR spectrum haves showed a new broad band at 574 cm-1 indicating to TiO2 with ferrous ion. The UV spectrum shows absorption peaks at 277.40, 396.30 and 453.30 nm, which tallies with the wavelength of the surface plasmon resonance (SPR) of Fe/TiO2 bimetallic NPs. The XRD peaks corresponding to rutile phase also emerged at 2 = 25.61(121) and 39.69 (004) diffraction corresponding to the Fe3+ ions could substitute Ti4+ from some of the lattice sites of TiO2. SEM, EDS and TEM images have showed very clear shapes of ferrous ion anatase, Antibacterial activity of green synthesized Fe/TiO2 has excellent zone of inhibition (14 mm) which is appreciable. Anticancer activities have showed significant effects (IC50= 62.5 μg/m.L). Novelty: The nanoparticles of Fe/TiO2 mediated by Beta vulgaris have acted as effective bioreductant and also as potential anticancer agent. Keywords: Green synthesis, Beta vulgaris, Fe/TiO2NPs, Antimicrobial, Antioxidant, Anticancer activity