Salidroside attenuates the acquisition of morphine‐induced conditioned place preference in mice via improving neurosynaptic plasticity in the ventral tegmental area

Our findings demonstrate that salidroside improves the synaptic structural and functional plasticity of VTA dopaminergic neurons through upregulating PI3K-AKT signalling, thereby attenuating the acquisition of morphine-induced CPP. Overall, salidroside exhibits promising preclinical potential as a therapeutic candidate for attenuating the acquisition of morphine-induced CPP.