基因组
生物
抗生素
计算生物学
管道(软件)
环境DNA
DNA测序
天然产物
生物技术
DNA
基因
遗传学
生态学
生物多样性
计算机科学
生物化学
程序设计语言
作者
Adam Rosenzweig,Ján Burian,Sean F. Brady
标识
DOI:10.1016/j.mib.2023.102335
摘要
Novel antibiotics are in constant demand to combat a global increase in antibiotic-resistant infections. Bacterial natural products have been a long-standing source of antibiotic compounds, and metagenomic mining of environmental DNA (eDNA) has increasingly provided new antibiotic leads. The metagenomic small-molecule discovery pipeline can be divided into three main steps: surveying eDNA, retrieving a sequence of interest, and accessing the encoded natural product. Improvements in sequencing technology, bioinformatic algorithms, and methods for converting biosynthetic gene clusters into small molecules are steadily increasing our ability to discover metagenomically encoded antibiotics. We predict that, over the next decade, ongoing technological improvements will dramatically increase the rate at which antibiotics are discovered from metagenomes.
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