子宫内膜癌
纳米医学
医学
癌症
卫生公平
恶性肿瘤
精密医学
死亡率
临床试验
重症监护医学
公共卫生
内科学
病理
纳米技术
纳米颗粒
材料科学
作者
Claire E Rowlands,Abigail M. Folberg,Zachary K Beickman,Eric J. Devor,Kimberly K. Leslie,Brittany E. Givens
出处
期刊:Small
[Wiley]
日期:2023-06-13
被引量:2
标识
DOI:10.1002/smll.202300096
摘要
Abstract Endometrial cancer is the most common gynecological malignancy worldwide and unfortunately has a much higher mortality rate in Black women compared with White women. Many potential factors contribute to these mortality rates, including the underlying effects of systemic and interpersonal racism. Furthermore, other trends in medicine have potential links to these rates including participation in clinical trials, hormone therapy, and pre‐existing health conditions. Addressing the high incidence and disparate mortality rates in endometrial cancer requires novel methods, such as nanoparticle‐based therapeutics. These therapeutics have been growing in increasing prevalence in pre‐clinical development and have far‐reaching implications in cancer therapy. The rigor of pre‐clinical studies is enhanced by the likeness of the model to the human body. In systems for 3D cell culture, for example, the extracellular matrix mimics the tumor more closely. The increasing emphasis on precision medicine can be applied to cancer using nanoparticle‐based methods and applied to pre‐clinical models by using patient‐derived model data. This review highlights the intersections of nanomedicine, precision medicine, and racial disparities within endometrial cancer and provides insights into reducing health disparities using recent scientific advances on the nanoscale.
科研通智能强力驱动
Strongly Powered by AbleSci AI