病态的
骨关节炎
医学
生物信息学
透视图(图形)
神经科学
内科学
心理学
病理
生物
计算机科学
人工智能
替代医学
作者
Guizheng Wei,Ke Lu,Muhammad Ihtisham Umar,Zhenglin Zhu,William W. Lu,John R. Speakman,Yan Chen,Liping Tong,Di Chen
出处
期刊:Bone research
[Springer Nature]
日期:2023-12-06
卷期号:11 (1)
被引量:2
标识
DOI:10.1038/s41413-023-00301-9
摘要
Abstract Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the association between metabolic abnormalities and OA, particularly in younger individuals. Metabolic abnormalities, such as obesity and type II diabetes, are strongly linked to OA, and they affect both weight-bearing and non-weight-bearing joints, thus suggesting that the pathogenesis of OA is more complicated than the mechanical stress induced by overweight. This review aims to explore the recent advances in research on the relationship between metabolic abnormalities and OA risk, including the impact of abnormal glucose and lipid metabolism, the potential pathogenesis and targeted therapeutic strategies.
科研通智能强力驱动
Strongly Powered by AbleSci AI