医学
肾病
蛋白尿
免疫学
重症监护医学
肾小球肾炎
临床试验
内科学
肾
糖尿病
内分泌学
作者
Haresh Selvaskandan,Jonathan Barratt,Chee Kay Cheung
标识
DOI:10.1016/j.ekir.2023.11.026
摘要
IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Around 30-45% of patients progress to kidney failure within 20-25 years of diagnosis, and there has long been a lack of effective treatments. The therapeutic landscape in IgAN is rapidly evolving, driven in large part by the acceptance of the surrogate clinical trial end point of proteinuria reduction by regulatory authorities for the accelerated approval of new therapies. Two drugs, targeted release formulation (TRF)-budesonide (Nefecon) and Sparsentan, have recently been approved under this scheme. Advancing insights into the pathophysiology of IgAN, including the roles of the mucosal immune system, B-cells, the complement system and the endothelin system have driven development of therapies that target these factors. This review outlines current, recently approved, and emerging therapies for IgAN.
科研通智能强力驱动
Strongly Powered by AbleSci AI