Implementation of High Throughput Experimentation across Medicinal Chemistry, Process Chemistry and Materials Science

High Throughput Experimentation (HTE) has revolutionized the pharmaceutical industry over the last two decades, developing from a technology for screening compounds against biological targets, to now being used for everything from parallel synthesis of diverse libraries of analogues and optimization of catalytic systems and reaction conditions, to screening for optimal crystallization solvents and API polymorphs. Many pharmaceutical companies (and several academic institutions) have invested in HTE capabilities (often including automation) to support their drug discovery pipelines and fundamental research. With HTE workflows now being firmly established and many successful HTE groups to draw inspiration from, new facilities being set up today have options on where and how to build and integrate new high throughput and automation capabilities into their organizations. This chapter discusses and classifies different options for the build and integration of high throughput experimentation resources into existing chemistry departments.